Article
Genetic polymorphism in the cathepsin G gene and the risk of Alzheimer's disease.
Neuroscience letters - 24 Aug 2001
Bhojak T J, DeKosky S T, Ganguli M, Kamboh M I
Abstract excerpt
Alzheimer's disease (AD) is a complex disease with the possible involvement of several genes. The APOE*4 allele has been documented to be a major risk factor for sporadic late-onset AD, but it is neither necessary nor sufficient to cause the disease. Cathepsin G, a serine protease found commonly in the azurophillic granules of neutrophils, has been reported to possess some beta-secretase like properties, and thus...
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