The cathepsin D (224C/T) polymorphism confers an increased risk to develop Alzheimer's disease in men.

doi:10.1093/gerona/glp209

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

The cathepsin D (224C/T) polymorphism confers an increased risk to develop Alzheimer's disease in men.

The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Mar 2010

Albayrak O, Tirniceriu A, Riemenschneider M, Kurz A, Scherag A, Egensperger Rupert

Abstract excerpt

The lysosomal protease cathepsin D is likely involved in beta-amyloidogenesis in Alzheimer's disease (AD). There is evidence for a single nucleotide polymorphism (rs17571) of the cathepsin D gene to be associated with increased AD risk. However, little is known about gender-specific differences. Therefore, we performed a genetic association study focusing on gender-specific differences in 434 participants (219 AD...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Alzheimer Disease

Share to Cathepsin D

Share to DNA

Share to Gene Frequency

Share to Germany

Share to Incidence

Share to Prognosis

Source

Open in PubMed

Identifiers

PMID: 20083556
DOI: 10.1093/gerona/glp209

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The cathepsin D (224C/T) polymorphism confers an increased risk to develop Alzheimer's disease in men.PMID 20083556Read ↗

Cathepsin D gene and the risk of Alzheimer's disease: a population-based study and meta-analysis.Semantic proximity Read ↗

Association study of cathepsin D gene polymorphism in Iranian patients with sporadic late-onset Alzheimer's disease.Semantic proximity Read ↗

Cathepsin D polymorphism in Italian elderly subjects with sporadic late-onset Alzheimer's disease.Semantic proximity Read ↗

Association between cathepsin D polymorphism and Alzheimer's disease in a Chinese Han population.Semantic proximity Read ↗

A genetic variation of cathepsin D is a major risk factor for Alzheimer's disease.Semantic proximity Read ↗

Meta-analysis of the association of the cathepsin D Ala224Val gene polymorphism with the risk of Alzheimer's disease: a HuGE gene-disease association review.Semantic proximity Read ↗

Genetic polymorphism of cathepsin D is strongly associated with the risk for developing sporadic Alzheimer's disease.Semantic proximity Read ↗

The cathepsin D rs17571 polymorphism: effects on CSF tau concentrations in Alzheimer disease.Semantic proximity Read ↗

The genetic association between Cathepsin D and Alzheimer's disease.Semantic proximity Read ↗

Non-replication of association between cathepsin D genotype and late onset Alzheimer disease.Semantic proximity Read ↗

The cathepsin D gene exon 2 (C224T) polymorphism and sporadic Alzheimer's disease in European populations.Semantic proximity Read ↗

[The C224T polymorphism in the cathepsin D gene is not associated with sporadic Alzheimer's disease in Chinese].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.