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Article

Lack of association between cathepsin D genetic polymorphism and Alzheimer disease in a Spanish sample.

American journal of medical genetics - 8 Jan 2002

Mateo Ignacio, Sánchez-Guerra Marisa, Combarros Onofre, Llorca Javier, Infante Jon, González-García Javier, del Molino Jesús Pérez, Berciano José

Abstract excerpt

Cathepsin D (catD) is an intracellular aspartyl protease that exhibits beta and gamma secretase-like activity to cleave amyloid precursor protein into beta amyloid peptide. The T-allele of a biallelic (alleles C and T) polymorphism in the exon 2 of the catD gene has been found to be associated with increased risk of Alzheimer disease (AD) in two independent German populations. Other groups have been unable to...

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PMID: 11840502
DOI: 10.1002/ajmg.1623

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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