Article
Genetic polymorphism of cathepsin D is strongly associated with the risk for developing sporadic Alzheimer's disease.
Neuroscience letters - 12 Mar 1999
Papassotiropoulos A, Bagli M, Feder O, Jessen F, Maier W, Rao M L, Ludwig M, Schwab S G, Heun R
Abstract excerpt
The beta amyloid peptide derives from its precursor protein via proteolytic cleavage of yet unidentified proteases (beta- and gamma-secretases). Cathepsin D is an intracellular protease with in-vitro beta-secretase-like features. An exonic polymorphism of the cathepsin D gene (alanine to valine transition at position 224, exon 2) has been associated with altered enzyme function. We tested the hypothesis that this...
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