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Article

Genetic polymorphism of cathepsin D is strongly associated with the risk for developing sporadic Alzheimer's disease.

Neuroscience letters - 12 Mar 1999

Papassotiropoulos A, Bagli M, Feder O, Jessen F, Maier W, Rao M L, Ludwig M, Schwab S G, Heun R

Abstract excerpt

The beta amyloid peptide derives from its precursor protein via proteolytic cleavage of yet unidentified proteases (beta- and gamma-secretases). Cathepsin D is an intracellular protease with in-vitro beta-secretase-like features. An exonic polymorphism of the cathepsin D gene (alanine to valine t...

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PMID: 10218883
DOI: 10.1016/s0304-3940(99)00071-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-10218883-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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Genetic polymorphism of cathepsin D is strongly associated with the risk for developing sporadic Alzheimer's disease.PMID 10218883Read ↗

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