Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

[The C224T polymorphism in the cathepsin D gene is not associated with sporadic Alzheimer's disease in Chinese].

Yi chuan = Hereditas - 1 Mar 2005

Sun Yan, Shi Jia-Jun, Zhang Si-Zhong, Tang Mu-Ni, Han Hai-Ying, Guo Yang-Bo, Ma Cui, Liu Xie-He, Li Tao

Abstract excerpt

Cathepsin D is the major lysosomal/endosomal aspartic protease and exhibits beta- and gamma-secretase-like activity in vitro. Data from German suggest that the C224T polymorphism in the Cathepsin D gene (CTSD) exon 2 is strongly associated with the risk for Alzheimer's disease (AD). Meanwhile other studies have not been able to replicate the result. It's necessary to determine the genotype of the polymorphism in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged, 80 and over
Share to Alzheimer Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Apolipoprotein E4

Share to Asian People

Share to Cathepsin D

Share to Gene Frequency

Source

Identifiers

PMID: 15843343

Genes

CTSD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

[The C224T polymorphism in the cathepsin D gene is not associated with sporadic Alzheimer's disease in Chinese].PMID 15843343Read ↗

Association between cathepsin D polymorphism and Alzheimer's disease in a Chinese Han population.Semantic proximity Read ↗

The cathepsin D gene exon 2 (C224T) polymorphism and sporadic Alzheimer's disease in European populations.Semantic proximity Read ↗

Cathepsin D polymorphism in Italian elderly subjects with sporadic late-onset Alzheimer's disease.Semantic proximity Read ↗

Association study of cathepsin D gene polymorphism in Iranian patients with sporadic late-onset Alzheimer's disease.Semantic proximity Read ↗

Meta-analysis of the association of the cathepsin D Ala224Val gene polymorphism with the risk of Alzheimer's disease: a HuGE gene-disease association review.Semantic proximity Read ↗

Genetic polymorphism in exon 2 of cathepsin D is not associated with vascular dementia.Semantic proximity Read ↗

Non-replication of association between cathepsin D genotype and late onset Alzheimer disease.Semantic proximity Read ↗

Genetic polymorphism of cathepsin D is strongly associated with the risk for developing sporadic Alzheimer's disease.Semantic proximity Read ↗

The cathepsin D (224C/T) polymorphism confers an increased risk to develop Alzheimer's disease in men.Semantic proximity Read ↗

A genetic variation of cathepsin D is a major risk factor for Alzheimer's disease.Semantic proximity Read ↗

Cathepsin D gene and the risk of Alzheimer's disease: a population-based study and meta-analysis.Semantic proximity Read ↗

Genetic association of a cathepsin D polymorphism and sporadic Creutzfeldt-Jakob disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.