Article
Association between cathepsin D polymorphism and Alzheimer's disease in a Chinese Han population.
Dementia and geriatric cognitive disorders - 1 Jan 2004
Li Xiao-Qing, Chen Deng, Zhang Zhen-Xin, Qu Qiu-Ming, Zhang Jun-Wu
Abstract excerpt
Cathepsin D (CTSD) is an intracellular aspartyl protease, which is active in the endosomal/lysosomal system. CTSD may play a role in Alzheimer's disease (AD) through cleaving the amyloid precursor protein into beta-amyloid peptide and degrading tau protein into fragments. A functional polymorphism in exon 2 of the cathepsin D gene (C-->T, Ala224Val) has recently been reported to increase the risk for AD in some...
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