Article
Tsix-Mecp2 female mouse model for Rett syndrome reveals that low-level MECP2 expression extends life and improves neuromotor function.
Proceedings of the National Academy of Sciences of the United States of America - 7 Aug 2018
Carrette Lieselot L G, Blum Roy, Ma Weiyuan, Kelleher Raymond J, Lee Jeannie T
Abstract excerpt
Rett syndrome (RTT) is a severe neurodevelopmental disorder caused by a mutation in the X-linked methyl-CpG-binding protein 2 (MECP2). There is currently no disease-specific treatment, but MECP2 restoration through reactivation of the inactive X (Xi) has been of considerable interest. Progress toward an Xi-reactivation therapy has been hampered by a lack of suitable female mouse models. Because of cellular...
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