Article
Prophylactic total gastrectomy in hereditary diffuse gastric cancer: identification of two novel CDH1 gene mutations-a clinical observational study.
Familial cancer - 1 Jun 2014
Bardram Linda, Hansen Thomas V O, Gerdes Anne-Marie, Timshel Susanne, Friis-Hansen Lennart, Federspiel Birgitte
Abstract excerpt
Inactivating mutations in the CDH1 (E-cadherin) gene are the predisposing cause of gastric cancer in most families with hereditary diffuse gastric cancer (HDGC). The lifetime risk of cancer in mutation positive members is more than 80 % and prophylactic total gastrectomy is recommended. Not all mutations in the CDH1 gene are however pathogenic and it is important to classify mutations before this major operation...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.