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Polymorphisms of the endothelial nitric oxide synthase gene in ovarian cancer.

Gynecologic oncology - 1 Aug 2002

Hefler Lukas A, Ludwig Elisabeth, Lampe Dieter, Zeillinger Robert, Leodolter Sepp, Gitsch Gerald, Koelbl Heinz, Tempfer Clemens B

Abstract excerpt

OBJECTIVE: The free radical nitric oxide is known to be critically involved in ovarian carcinogenesis by inducing apoptosis and by mediating various cytostatic and cytotoxic effects, but also by promoting growth, invasion, and metastasis. METHODS: We investigated two polymorphisms (exon 7 Glu298Asp and a 27-bp repeat in intron 4) of the gene encoding endothelial nitric oxide synthase (Nos3) in 130 patients with...

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Identifiers

PMID: 12144818
DOI: 10.1006/gyno.2002.6749

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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