Polymorphisms in nitric-oxide synthase 3 may influence the risk of urinary-bladder cancer.

doi:10.1016/j.niox.2011.06.003

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Article

Polymorphisms in nitric-oxide synthase 3 may influence the risk of urinary-bladder cancer.

Nitric oxide : biology and chemistry - 30 Oct 2011

Ryk Charlotta, Wiklund N Peter, Nyberg Tommy, de Verdier Petra J

Abstract excerpt

Nitric oxide (NO) is an important biological messenger known to influence several types of human cancers. NO formation is catalyzed by three different nitric oxide synthase (NOS) enzymes. In this study we analyzed if the NOS3 promoter polymorphism -786T>C (rs2070744) and the NOS3 Glu298Asp polymorphism in exon 7 (rs1799983) influence risk and pathogenesis of urinary-bladder cancer. Allelic discrimination and DNA...

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Identifiers

PMID: 21703358
DOI: 10.1016/j.niox.2011.06.003

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NOS3

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