Article
Genetic polymorphisms in the endothelial nitric oxide synthase gene correlate with overall survival in advanced non-small-cell lung cancer patients treated with platinum-based doublet chemotherapy.
BMC medical genetics - 30 Nov 2010
Fujita Shiro, Masago Katsuhiro, Hatachi Yukimasa, Fukuhara Akiko, Hata Akito, Kaji Reiko, Kim Young Hak, Mio Tadashi, Mishima Michiaki, Katakami Nobuyuki
Abstract excerpt
BACKGROUND: Nitric oxide (NO) is a free radical that is involved in carcinogenesis. Endothelial NO, synthesized from L-arginine by endothelial NO synthase (eNOS), inhibits apoptosis and promotes angiogenesis, tumor cell proliferation and metastasis. The aim of this study was to evaluate the influ...
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