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Article

Vascular invasion in human breast cancer is correlated to T-->786C polymorphism of NOS3 gene.

Nitric oxide : biology and chemistry - 1 Sept 2003

Ghilardi Giorgio, Biondi Maria Luisa, Cecchini Federica, DeMonti Marco, Guagnellini Emma, Scorza Roberto

Abstract excerpt

BACKGROUND: Nitric oxide (NO) is a free radical known to be a major regulator of vascular tonus, to inhibit cell proliferation, induce apoptosis, and be a mediator of macrophage cytostatic and cytotoxic effects. Recently, NO synthesis has been reported to be elevated in different cancers and is expected to promote metastasis by maintaining a vasodilator tone in blood vessels in and around the tumour. Two...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14623178
DOI: 10.1016/j.niox.2003.09.002

Genes

NOS3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Vascular invasion in human breast cancer is correlated to T-->786C polymorphism of NOS3 gene.PMID 14623178Read ↗

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Abnormal Expression of NOS3 and Association with Clinical Outcome are Highly Cancer Dependent as Revealed through Pan-Cancer AnalysisSemantic proximity Read ↗

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Promoter polymorphism (−786t>C) in the endothelial nitric oxide synthase gene is associated with risk of sporadic breast cancer in non‐Hispanic white women age younger than 55 yearsSemantic proximity Read ↗

The Relationship Between eNOS Polymorphisms With Age, Smoking, Body Mass Index, and Clinicopathologic Parameters in Patients With Breast Cancer in Comparison With a Control Group.Semantic proximity Read ↗

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New Findings in eNOS gene and Thalidomide Embryopathy Suggest pre-transcriptional effect variants as susceptibility factors.Semantic proximity Read ↗

Nitric oxide synthase 3 gene variants and colorectal cancer: a meta-analysis.Semantic proximity Read ↗

The -786T > C polymorphism in the NOS3 gene is associated with increased cancer risk.Semantic proximity Read ↗

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