Article
Polymorphisms of the endothelial nitric oxide synthase gene in women with vulvar cancer.
Gynecologic oncology - 1 Jun 2004
Riener Eva-Katrin, Hefler Lukas A, Grimm Christoph, Galid Arik, Zeillinger Robert, Tong-Cacsire Dan, Gitsch Gerald, Leodolter Sepp, Tempfer Clemens B
Abstract excerpt
OBJECTIVE: Nitric oxide (NO) is involved in angiogenesis and tumor growth. We attempted to establish an association between two polymorphisms of the endothelial nitric oxide synthase (NOS3) gene and vulvar cancer. METHODS: We used peripheral venous blood sampling, DNA extraction, and polymerase chain reaction (PCR) and pyrosequencing to genotype 68 women with vulvar cancer and 227 healthy Caucasian women for the...
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