Article
Molecular modeling of transmembrane helices 6 and 7 of the heptahelical lutropin receptor.
Protein and peptide letters - 1 Apr 2002
Simon J Paul, Angelova Krassimira, Puett David
Abstract excerpt
In response to ligand binding and activating mutations, the lutropin receptor undergoes a conformational change to trigger a cellular response. D556 is the most common locus for naturally occurring activating mutations of the lutropin receptor, and a D556A mutant is shown to be constitutively active. A water-mediated proton transfer is postulated as part of the transmembrane signaling mechanism. Using energy...
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