Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of deleterious nsSNPs of klotho protein and their drug response: a computational mechanical insights.

Journal of biomolecular structure & dynamics - 1 Apr 2024

Jayaraj John Marshal, Muthusamy Karthikeyan

Abstract excerpt

Worldwide, the burden of chronic kidney disease (CKD) has increased rapidly and is a lethal disease. The klotho protein plays a vital role in the regulatory mechanism in the progression of CKD. Particularly the decreased expression of klothoand its genetic variations might affect the potency of drugs. This study aims to identify a new drug molecule, which works equipotential in all types of klotholike wild and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Klotho Proteins
Share to Molecular Dynamics Simulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation, Missense

Share to Polymorphism, Single Nucleotide

Share to Renal Insufficiency, Chronic

Source

Identifiers

PMID: 37216366
DOI: 10.1080/07391102.2023.2214230

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of deleterious nsSNPs of klotho protein and their drug response: a computational mechanical insights.PMID 37216366Read ↗

Structural and functional insights on vitamin D receptor and CYP24A1 deleterious single nucleotide polymorphisms: A computational and pharmacogenomics perpetual approach.Semantic proximity Read ↗

Mechanistic insights on nsSNPs on binding site of renin and cytochrome P450 proteins: A computational perceptual study for pharmacogenomics evaluation.Semantic proximity Read ↗

In-Silico Analysis of nsSNPs Associated with CYP11B2 GeneSemantic proximity Read ↗

Assessment of structurally and functionally high-risk nsSNPs impacts on human bone morphogenetic protein receptor type IA (BMPR1A) by computational approachSemantic proximity Read ↗

Predicting the impact of deleterious mutations in the protein kinase domain of FGFR2 in the context of function, structure, and pathogenesis--a bioinformatics approach.Semantic proximity Read ↗

Structural characterization and mutational assessment of podocin - a novel drug target to nephrotic syndrome - an in silico approach.Semantic proximity Read ↗

Discovery of Klotho peptide antagonists against Wnt3 and Wnt3a target proteins using combination of protein engineering, protein–protein docking, peptide docking and molecular dynamics simulationsSemantic proximity Read ↗

Dissecting Mutational Allosteric Effects in Alkaline Phosphatases Associated with Different Hypophosphatasia Phenotypes: An Integrative Computational InvestigationSemantic proximity Read ↗

Vitamin D receptor (VDR) non-synonymous single nucleotide polymorphisms (nsSNPs) affect the calcitriol drug response - A theoretical insight.Semantic proximity Read ↗

The association between Single Nucleotide Polymorphisms of Klotho Gene and Mortality in Elderly Men: The MrOS Sweden Study.Semantic proximity Read ↗

Impacts of Nonsynonymous Single Nucleotide Polymorphisms of Adiponectin Receptor 1 Gene on Corresponding Protein Stability: A Computational Approach.Semantic proximity Read ↗

In-silico assessment of high-risk non-synonymous SNPs in ADAMTS3 gene associated with Hennekam syndrome and their impact on protein stability and function.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.