Article
From molecular details of the interplay between transmembrane helices of the thyrotropin receptor to general aspects of signal transduction in family a G-protein-coupled receptors (GPCRs).
The Journal of biological chemistry - 22 Jul 2011
Kleinau Gunnar, Hoyer Inna, Kreuchwig Annika, Haas Ann-Karin, Rutz Claudia, Furkert Jens, Worth Catherine L, Krause Gerd, Schülein Ralf
Abstract excerpt
Transmembrane helices (TMHs) 5 and 6 are known to be important for signal transduction by G-protein-coupled receptors (GPCRs). Our aim was to characterize the interface between TMH5 and TMH6 of the thyrotropin receptor (TSHR) to gain molecular insights into aspects of signal transduction and regulation. A proline at TMH5 position 5.50 is highly conserved in family A GPCRs and causes a twist in the helix...
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