Article
Structural and functional roles of small group-conserved amino acids present on helix-H7 in the β(2)-adrenergic receptor.
Biochimica et biophysica acta - 1 Apr 2011
Arakawa Makoto, Chakraborty Raja, Upadhyaya Jasbir, Eilers Markus, Reeves Philip J, Smith Steven O, Chelikani Prashen
Abstract excerpt
Sequence analysis of the class A G protein-coupled receptors (GPCRs) reveals that most of the highly conserved sites are located in the transmembrane helices. A second level of conservation exists involving those residues that are conserved as a group characterized by small and/or weakly polar side chains (Ala, Gly, Ser, Cys, Thr). These positions can have group conservation levels of up to 99% across the class A...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.