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Article

Contributions of intracellular loops 2 and 3 of the lutropin receptor in Gs coupling.

Molecular endocrinology (Baltimore, Md.) - 1 Jan 2008

Angelova Krassimira, Fanelli Francesca, Puett David

Abstract excerpt

A number of amino acids essential for Gs coupling, i.e. hot spots, were identified after in vitro Ala-scanning mutagenesis of the cytosolic extensions of helices 3, 5, and 6 and of intracellular loops 2 and 3 (IL2 and IL3) of the human LH receptor (LHR). Consistent with the results of in vitro experiments involving ligand binding and ligand-mediated signaling in transiently transfected human embryonic kidney 293...

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Identifiers

PMID: 17872379
DOI: 10.1210/me.2007-0352
PMCID: PMC2194637

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Contributions of intracellular loops 2 and 3 of the lutropin receptor in Gs coupling.PMID 17872379Read ↗

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