An alpha-tubulin mutant demonstrates distinguishable functions among the spindle assembly checkpoint genes in Saccharomyces cerevisiae.

doi:10.1093/genetics/161.3.983

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Article

An alpha-tubulin mutant demonstrates distinguishable functions among the spindle assembly checkpoint genes in Saccharomyces cerevisiae.

Genetics - 1 Jul 2002

Abruzzi Katharine C, Magendantz Margaret, Solomon Frank

Abstract excerpt

Cells expressing a mutant allele of alpha-tubulin, tub1-729, are cold sensitive and arrest as large-budded cells with microtubule defects. The cold sensitivity of tub1-729 is suppressed by extra copies of a subset of the mitotic checkpoint genes BUB1, BUB3, and MPS1, but not MAD1, MAD2, and MAD3. This suppression by checkpoint genes does not depend upon their role in the MAD2-dependent spindle assembly...

Topics

Alleles
Base Sequence
Chromosomes, Fungal
DNA Primers
Genes, Fungal
Genotype
Mitosis
Plasmids
Polymerase Chain Reaction
Saccharomyces cerevisiae
Spindle Apparatus
Temperature
Tubulin

Source

Open in PubMed Open full text

Identifiers

PMID: 12136005
DOI: 10.1093/genetics/161.3.983
PMCID: PMC1462169

Genes

BUB1
BUB3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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