Article
Structure-function relationships in yeast tubulins.
Molecular biology of the cell - 1 May 2000
Richards K L, Anders K R, Nogales E, Schwartz K, Downing K H, Botstein D
Abstract excerpt
A comprehensive set of clustered charged-to-alanine mutations was generated that systematically alter TUB1, the major alpha-tubulin gene of Saccharomyces cerevisiae. A variety of phenotypes were observed, including supersensitivity and resistance to the microtubule-destabilizing drug benomyl, lethality, and cold- and temperature-sensitive lethality. Many of the most benomyl-sensitive tub1 alleles were...
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