Article
The V260I mutation in fission yeast alpha-tubulin Atb2 affects microtubule dynamics and EB1-Mal3 localization and activates the Bub1 branch of the spindle checkpoint.
Molecular biology of the cell - 1 Mar 2006
Asakawa Kazuhide, Kume Kazunori, Kanai Muneyoshi, Goshima Tetsuya, Miyahara Kohji, Dhut Susheela, Tee Wee Wei, Hirata Dai, Toda Takashi
Abstract excerpt
We have identified a novel temperature-sensitive mutant of fission yeast alpha-tubulin Atb2 (atb2-983) that contains a single amino acid substitution (V260I). Atb2-983 is incorporated into the microtubules, and their overall structures are not altered noticeably, but microtubule dynamics is compromised during interphase. atb2-983 displays a high rate of chromosome missegregation and is synthetically lethal with...
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