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Article

STU1, a suppressor of a beta-tubulin mutation, encodes a novel and essential component of the yeast mitotic spindle.

The Journal of cell biology - 1 Dec 1994

Pasqualone D, Huffaker T C

Abstract excerpt

We have isolated a cold-sensitive allele of TUB2, the sole gene encoding beta-tubulin in S. cerevisiae, that confers a specific defect in spindle microtubule function. At 14 degrees C, tub2-406 cells lack a normal bipolar spindle but do assemble functional cytoplasmic microtubules. In an attempt to identify proteins that are important for spindle assembly, we screened for suppressors of the cold-sensitivity of...

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Identifiers

PMID: 7806575
DOI: 10.1083/jcb.127.6.1973
PMCID: PMC2120270

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Click a neighbor to travelStep 1 · 12 closest

STU1, a suppressor of a beta-tubulin mutation, encodes a novel and essential component of the yeast mitotic spindle.PMID 7806575Read ↗

Stu2p: A microtubule-binding protein that is an essential component of the yeast spindle pole body.Semantic proximity Read ↗

Stu1p is physically associated with beta-tubulin and is required for structural integrity of the mitotic spindle.Semantic proximity Read ↗

Control of microtubule dynamics by Stu2p is essential for spindle orientation and metaphase chromosome alignment in yeast.Semantic proximity Read ↗

Spc24 and Stu2 promote spindle integrity when DNA replication is stalled.Semantic proximity Read ↗

The XMAP215 homologue Stu2 at yeast spindle pole bodies regulates microtubule dynamics and anchorage.Semantic proximity Read ↗

Analysis of Tub4p, a yeast gamma-tubulin-like protein: implications for microtubule-organizing center function.Semantic proximity Read ↗

Stu2p binds tubulin and undergoes an open-to-closed conformational change.Semantic proximity Read ↗

Microtubule stability in budding yeast: characterization and dosage suppression of a benomyl-dependent tubulin mutant.Semantic proximity Read ↗

Stu2 performs an essential kinetochore function independent of its microtubule polymerase activity.Semantic proximity Read ↗

Sto1p, a fission yeast protein similar to tubulin folding cofactor E, plays an essential role in mitotic microtubule assembly.Semantic proximity Read ↗

The Saccharomyces cerevisiae homolog of p24 is essential for maintaining the association of p150Glued with the dynactin complex.Semantic proximity Read ↗

A highly divergent gamma-tubulin gene is essential for cell growth and proper microtubule organization in Saccharomyces cerevisiae.Semantic proximity Read ↗

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