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Article

Intermolecular interactions, nucleation, and thermodynamics of crystallization of hemoglobin C.

Biophysical journal - 1 Aug 2002

Vekilov Peter G, Feeling-Taylor Angela R, Petsev Dimiter N, Galkin Oleg, Nagel Ronald L, Hirsch Rhoda Elison

Abstract excerpt

The mutated hemoglobin HbC (beta 6 Glu-->Lys), in the oxygenated (R) liganded state, forms crystals inside red blood cells of patients with CC and SC diseases. Static and dynamic light scattering characterization of the interactions between the R-state (CO) HbC, HbA, and HbS molecules in low-ionic-strength solutions showed that electrostatics is unimportant and that the interactions are dominated by the specific...

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Identifiers

PMID: 12124294
DOI: 10.1016/S0006-3495(02)75238-7
PMCID: PMC1302216

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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