Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Impact of hemoglobin biophysical studies on molecular pathogenesis and drug therapy for sickle cell disease

14 Jul 2021

Abstract excerpt

Basic research on hemoglobin has been essential for understanding the origin and treatment of many hematological disorders due to abnormal hemoglobins. The most important of the hemoglobinopathies is sickle cell disease - Linus Pauling's "molecular disease" that gave birth to molecular medicine. In this review, I will describe the contributions of basic biophysical research on normal and sickle cell hemoglobin...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Erythrocyte Function and Pathophysiology
Share to Hemoglobin structure and function
Share to Hemoglobinopathies and Related Disorders

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34274158
DOI: 10.1016/j.mam.2021.100971

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 17 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impact of hemoglobin biophysical studies on molecular pathogenesis and drug therapy for sickle cell diseasePMID 34274158Read ↗

Quantitative prediction of erythrocyte sickling for the development of advanced sickle cell therapiesSemantic proximity Read ↗

[Molecular and cellular pathophysiology of sickle cell anemia].Semantic proximity Read ↗

Sickle hemoglobin polymer stability probed by triple and quadruple mutant hybrids.Semantic proximity Read ↗

Biophysical Basis of Hb-S Polymerization in Red Blood Cell SicklingSemantic proximity Read ↗

Structure-Function Relations of Human HemoglobinsSemantic proximity Read ↗

Roles of alpha 114 and beta 87 amino acid residues in the polymerization of hemoglobin S: implications for gene therapy.Semantic proximity Read ↗

Enhanced inhibition of polymerization of sickle cell hemoglobin in the presence of recombinant mutants of human fetal hemoglobin with substitutions at position 43 in the gamma-chain.Semantic proximity Read ↗

Kinetics of sickle cell biorheology and implications for painful vasoocclusive crisis.Semantic proximity Read ↗

In Silico Post-screening of Anti-polymerization Agents to Treat Sickle Cell DiseaseSemantic proximity Read ↗

Oxygen-dependent flow of sickle trait blood as an in vitro therapeutic benchmark for sickle cell disease treatments.Semantic proximity Read ↗

Metastable mesoscopic clusters in solutions of sickle-cell hemoglobin.Semantic proximity Read ↗

Band 3 catalyzes sickle hemoglobin polymerization.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.