Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Metastable mesoscopic clusters in solutions of sickle-cell hemoglobin.

Biophysical journal - 1 Jan 2007

Pan Weichun, Galkin Oleg, Filobelo Luis, Nagel Ronald L, Vekilov Peter G

Abstract excerpt

Sickle cell hemoglobin (HbS) is a mutant, whose polymerization while in deoxy state in the venous circulation underlies the debilitating sickle cell anemia. It has been suggested that the nucleation of the HbS polymers occurs within clusters of dense liquid, existing in HbS solutions. We use dyna...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Light
Share to Biophysics
Share to Hemoglobin, Sickle

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hemoglobins

Share to Molecular Conformation

Share to Polymers

Share to Scattering, Radiation

Share to Thermodynamics

Source

Open in PubMed Open full text

Identifiers

PMID: 17040989
DOI: 10.1529/biophysj.106.094854
PMCID: PMC1697867

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17040989-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Metastable mesoscopic clusters in solutions of sickle-cell hemoglobin.PMID 17040989Read ↗

Quantitative prediction of erythrocyte sickling for the development of advanced sickle cell therapiesSemantic proximity Read ↗

Flexibility and nucleation in sickle hemoglobin.Semantic proximity Read ↗

Impact of hemoglobin biophysical studies on molecular pathogenesis and drug therapy for sickle cell diseaseSemantic proximity Read ↗

Band 3 catalyzes sickle hemoglobin polymerization.Semantic proximity Read ↗

Phase-separating RNA-binding proteins form heterogeneous distributions of clusters in subsaturated solutions.Semantic proximity Read ↗

Intermolecular interactions, nucleation, and thermodynamics of crystallization of hemoglobin C.Semantic proximity Read ↗

Liquid-liquid phase separation in hemoglobins: distinct aggregation mechanisms of the beta6 mutants.Semantic proximity Read ↗

Relationship between beta4 hydrogen bond and beta6 hydrophobic interactions during aggregate, fiber or crystal formation in oversaturated solutions of hemoglobin A and S.Semantic proximity Read ↗

Real time monitoring of sickle cell hemoglobin fiber formation by UV resonance Raman spectroscopy.Semantic proximity Read ↗

Sickle hemoglobin polymer stability probed by triple and quadruple mutant hybrids.Semantic proximity Read ↗

Distal heme pocket conformers of carbonmonoxy derivatives of Ascaris hemoglobin: evidence of conformational trapping in porous sol-gel matrices.Semantic proximity Read ↗

The structural link between polymerization and sickle cell disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.