Molecular interactions between Hb alpha-G Philadelphia, HbC, and HbS: phenotypic implications for SC alpha-G Philadelphia disease.

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Molecular interactions between Hb alpha-G Philadelphia, HbC, and HbS: phenotypic implications for SC alpha-G Philadelphia disease.

Blood - 1 Oct 1997

Lawrence C, Hirsch R E, Fataliev N A, Patel S, Fabry M E, Nagel R L

Abstract excerpt

We show here that alpha2(G-Phila.) beta2(C) has an increased rate of crystal nucleation compared to alpha2 beta2(C) (HbC). We conclude from this finding that position alpha68, the mutation site of alpha2(G-Phila.) beta2 (HbG(Philadelphia)), is a contact site in the crystal of HbC. In addition, th...

Topics

Adult
Blood Protein Electrophoresis
Crystallization
Erythrocytes, Abnormal
Female
Hemoglobin C
Hemoglobin, Sickle
Hemoglobinopathies
Hemoglobins, Abnormal
Humans
Isoelectric Focusing
Kinetics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Macromolecular Substances

Male

Microscopy, Electron, Scanning

Oxyhemoglobins

Pedigree

Phenotype

Source

Open in PubMed

Identifiers

PMID: 9326250

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9326250-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Molecular interactions between Hb alpha-G Philadelphia, HbC, and HbS: phenotypic implications for SC alpha-G Philadelphia disease.PMID 9326250Read ↗

Two different mutations in codon 68 are observed in Hb G-Philadelphia heterozygotes.Semantic proximity Read ↗

Impact of hemoglobin biophysical studies on molecular pathogenesis and drug therapy for sickle cell diseaseSemantic proximity Read ↗

Band 3 catalyzes sickle hemoglobin polymerization.Semantic proximity Read ↗

Haemoglobin (Hb) G-Philadelphia, Hb Stanleyville-II, Hb G-Norfolk, Hb Matsue-Oki and Hb Mizushi can form a panel of α-chain variants that overlap in their phenotype: the novel use of StyI to screen for Hb G-Philadelphia.Semantic proximity Read ↗

Linkage of interactions in sickle hemoglobin fiber assembly: inhibitory effect emanating from mutations in the AB region of the alpha-chain is annulled by a mutation at its EF corner.Semantic proximity Read ↗

The structural link between polymerization and sickle cell disease.Semantic proximity Read ↗

Intermolecular interactions, nucleation, and thermodynamics of crystallization of hemoglobin C.Semantic proximity Read ↗

Sickle Cell Disease: Genetics, Cellular and Molecular Mechanisms, and TherapiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.