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Article

Band 3 catalyzes sickle hemoglobin polymerization.

Biophysical chemistry - 1 Feb 2010

Rotter Maria A, Chu Haiyan, Low Philip S, Ferrone Frank A

Abstract excerpt

We have measured homogeneous and heterogeneous nucleation rates of sickle hemoglobin (HbS) in the presence of a strongly binding deletion mutant of the cytoplasmic domain of band 3 (cdb3), a membrane protein known to form dimers and to bind 2 HbS molecules to such a dimer, and we find that it accelerated both rates by a factor of 2. A weakly binding mutant, in contrast showed no impact on nucleation rates,...

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Share to Anion Exchange Protein 1, Erythrocyte
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Share to Hemoglobin, Sickle

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19880238
DOI: 10.1016/j.bpc.2009.10.004
PMCID: PMC2989409

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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