Structural mapping of an aggregation nucleation site in a molten globule intermediate.

doi:10.1074/jbc.274.46.32897

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Article

Structural mapping of an aggregation nucleation site in a molten globule intermediate.

The Journal of biological chemistry - 12 Nov 1999

Hammarström P, Persson M, Freskgârd P O, Mârtensson L G, Andersson D, Jonsson B H, Carlsson U

Abstract excerpt

Protein aggregation plays an important role in biotechnology and also causes numerous diseases. Human carbonic anhydrase II is a suitable model protein for studying the mechanism of aggregation. We found that a molten globule state of the enzyme formed aggregates. The intermolecular interactions involved in aggregate formation were localized in a direct way by measuring excimer formation between each of 20...

Topics

Carbonic Anhydrases
Chaperonin 60
Cysteine
Fluorescent Dyes
Humans
Maleimides
Models, Molecular
Mutation
Protein Conformation
Protein Denaturation
Protein Folding
Protein Structure, Secondary
Spectrometry, Fluorescence
Tryptophan

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Open in PubMed

Identifiers

PMID: 10551854
DOI: 10.1074/jbc.274.46.32897

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