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Article

Liquid-liquid phase separation in hemoglobins: distinct aggregation mechanisms of the beta6 mutants.

Biophysical journal - 1 Mar 2004

Chen Qiuying, Vekilov Peter G, Nagel Ronald L, Hirsch Rhoda Elison

Abstract excerpt

Reversible liquid-liquid (L-L) phase separation in the form of high concentration hemoglobin (Hb) solution droplets is favored in an equilibrium with a low-concentration Hb solution when induced by inositol-hexaphosphate in the presence of polyethylene glycol 4000 at pH 6.35 HEPES (50 mM). The L-L phase separation of Hb serves as a model to elucidate intermolecular interactions that may give rise to accelerated...

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Identifiers

PMID: 14990498
DOI: 10.1016/S0006-3495(04)74239-3
PMCID: PMC1304006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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