Effects of different beta73 amino acids on formation of 14-stranded fibers of Hb S versus double-stranded crystals of Hb C-Harlem.

doi:10.1021/bi026740x

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Article

Effects of different beta73 amino acids on formation of 14-stranded fibers of Hb S versus double-stranded crystals of Hb C-Harlem.

Biochemistry - 22 Apr 2003

Adachi Kazuhiko, Ding Min, Wehrli Suzanne, Reddy Konda S, Surrey Saul, Horiuchi Kazumi

Abstract excerpt

Hb S (alpha(2)beta(2)(6Glu-->Val)) forms polymers, while Hb C-Harlem (alpha(2)beta(2)(6Glu-->Val,73Asp-->Asn)) forms crystals upon oversaturation. Since the only difference between the two is the beta73 amino acid, it follows that this site is a critical determinant in promoting either polymerization or crystallization. Beta73 Asp in Hb S forms a hydrogen bond with beta4 Thr, while beta73 Asn in Hb C-Harlem may...

Topics

Crystallization
Hemoglobin C
Hemoglobin, Sickle
Humans
Kinetics
Microscopy, Interference
Mutation

Source

Open in PubMed

Identifiers

PMID: 12693943
DOI: 10.1021/bi026740x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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