Article
Flexibility and nucleation in sickle hemoglobin.
Journal of molecular biology - 7 Dec 2001
Ivanova M, Jasuja R, Krasnosselskaia L, Josephs R, Wang Z, Ding M, Horiuchi K, Adachi K, Ferrone F A
Abstract excerpt
We have studied the self-assembly of Hemoglobin C-Harlem (HbC-Harlem), a double mutant of hemoglobin that possesses the beta6 Glu-->Val mutation of sickle hemoglobin (HbS) plus beta73 Asp-->Asn. By electron microscopy we find it forms crystals, rather than the wrapped multistranded fibers seen in...
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