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Article

Flexibility and nucleation in sickle hemoglobin.

Journal of molecular biology - 7 Dec 2001

Ivanova M, Jasuja R, Krasnosselskaia L, Josephs R, Wang Z, Ding M, Horiuchi K, Adachi K, Ferrone F A

Abstract excerpt

We have studied the self-assembly of Hemoglobin C-Harlem (HbC-Harlem), a double mutant of hemoglobin that possesses the beta6 Glu-->Val mutation of sickle hemoglobin (HbS) plus beta73 Asp-->Asn. By electron microscopy we find it forms crystals, rather than the wrapped multistranded fibers seen in HbS. Fourier transforms of the crystals yield unit cell parameters indistinguishable from crystals of HbS....

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Source

Identifiers

PMID: 11734002
DOI: 10.1006/jmbi.2001.5163

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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