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Article

Surface Exposed Free Cysteine Suppresses Crystallization of Human γD-Crystallin.

Journal of molecular biology - 5 Nov 2021

Strofaldi Alessandro, Khan Amir R, McManus Jennifer J

Abstract excerpt

Human γD-crystallin (HGD) has remarkable stability against condensation in the human lens, sometimes over a whole lifetime. The native protein has a surface exposed free cysteine that forms dimers (Benedek, 1997; Ramkumar et al., 1864)1,2 without specific biological function and leads to further protein association and/or aggregation, which creates a paradox for understanding its stability. Previous work has...

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Identifiers

PMID: 34537240
DOI: 10.1016/j.jmb.2021.167252

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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