Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Quantitative prediction of erythrocyte sickling for the development of advanced sickle cell therapies

2 Aug 2019

Abstract excerpt

Sickle cell disease is induced by a mutation that converts normal adult hemoglobin to sickle hemoglobin (HbS) and engenders intracellular polymerization of deoxy-HbS and erythrocyte sickling. Development of anti-sickling therapies requires quantitative understanding of HbS polymerization kinetics under organ-specific conditions, which are difficult to assess with existing experimental techniques. Thus, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Erythrocyte Function and Pathophysiology
Share to Hemoglobinopathies and Related Disorders
Share to Iron Metabolism and Disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31457104
DOI: 10.1126/sciadv.aax3905

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Quantitative prediction of erythrocyte sickling for the development of advanced sickle cell therapiesPMID 31457104Read ↗

Impact of hemoglobin biophysical studies on molecular pathogenesis and drug therapy for sickle cell diseaseSemantic proximity Read ↗

In Silico Post-screening of Anti-polymerization Agents to Treat Sickle Cell DiseaseSemantic proximity Read ↗

Targeting sickle cell disease root-cause pathophysiology with small moleculesSemantic proximity Read ↗

Phenotypic screening of the ReFrame Drug Repurposing Library to discover new drugs for treating sickle cell diseaseSemantic proximity Read ↗

Band 3 catalyzes sickle hemoglobin polymerization.Semantic proximity Read ↗

Kinetics of sickle cell biorheology and implications for painful vasoocclusive crisis.Semantic proximity Read ↗

Pathophysiological-Based Approaches to Treatment of Sickle Cell DiseaseSemantic proximity Read ↗

Optimal control strategies for inhibition of protein aggregationSemantic proximity Read ↗

Flexibility and nucleation in sickle hemoglobin.Semantic proximity Read ↗

Metastable mesoscopic clusters in solutions of sickle-cell hemoglobin.Semantic proximity Read ↗

Osivelotor for the treatment of sickle cell diseaseSemantic proximity Read ↗

VZHE-039, a novel antisickling agent that prevents erythrocyte sickling under both hypoxic and anoxic conditionsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.