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Article

Structure of human CD1b with bound ligands at 2.3 A, a maze for alkyl chains.

Nature immunology - 1 Aug 2002

Gadola Stephan D, Zaccai Nathan R, Harlos Karl, Shepherd Dawn, Castro-Palomino Julio C, Ritter Gerd, Schmidt Richard R, Jones E Yvonne, Cerundolo Vincenzo

Abstract excerpt

The human genome encodes five nonpolymorphic major histocompatibility complex class I-like glycoproteins, CD1a to CD1e, that present lipid antigens for specific recognition by T lymphocytes. Using single alkyl chain detergents, we developed a protocol to generate recombinant human CD1b-lipid complexes. We present here the crystal structures of CD1b in complex with either phosphatidylinositol or ganglioside GM2 at...

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Identifiers

PMID: 12118248
DOI: 10.1038/ni821

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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