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Article

Redesigning HVEM Interface for Selective Binding to LIGHT, BTLA, and CD160.

Structure (London, England : 1993) - 3 Nov 2020

Shrestha Rojan, Garrett-Thomson Sarah C, Liu Weifeng, Almo Steven C, Fiser Andras

Abstract excerpt

Herpes virus entry mediator (HVEM) regulates positive and negative signals for T cell activation through co-signaling pathways. Dysfunction of the HVEM co-signaling network is associated with multiple pathologies related to autoimmunity, infectious disease, and cancer, making the associated molecules biologically and therapeutically attractive targets. HVEM interacts with three ligands from two different...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32795404
DOI: 10.1016/j.str.2020.07.013
PMCID: PMC7642093

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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