Article
Structural determinants of APOBEC3B non-catalytic domain for molecular assembly and catalytic regulation.
Nucleic acids research - 7 Jul 2017
Xiao Xiao, Yang Hanjing, Arutiunian Vagan, Fang Yao, Besse Guillaume, Morimoto Cherie, Zirkle Brett, Chen Xiaojiang S
Abstract excerpt
The catalytic activity of human cytidine deaminase APOBEC3B (A3B) has been correlated with kataegic mutational patterns within multiple cancer types. The molecular basis of how the N-terminal non-catalytic CD1 regulates the catalytic activity and consequently, biological function of A3B remains relatively unknown. Here, we report the crystal structure of a soluble human A3B-CD1 variant and delineate several...
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