Article

Structural principles of B-cell antigen receptor assembly

2022-08-15

Abstract excerpt

The B-cell antigen receptor (BCR) is composed of a membrane-bound immunoglobulin (mIg) of class M, D, G, A or E for antigen recognition and a disulfide-linked heterodimer between Igα and Igβ (Igα/β, also known as CD79A and CD79B) that functions as the signalling entity. The organizing principle of BCR assembly remains elusive. Here we report the cryo-electron microscopy structures of the intact IgM class BCR at 8....

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Literature Corpus work: 98666188-0832-5796-8b73-554dcd9bd781
DOI: 10.1101/2022.08.13.503858

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