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Article

Impairment of store-operated Ca2+ entry in TRPC4(-/-) mice interferes with increase in lung microvascular permeability.

Circulation research - 12 Jul 2002

Tiruppathi Chinnaswamy, Freichel Marc, Vogel Stephen M, Paria Biman C, Mehta Dolly, Flockerzi Veit, Malik Asrar B

Abstract excerpt

We investigated the possibility that the TRPC gene family of putative store-operated Ca2+ entry channels contributes to the increase in microvascular endothelial permeability by prolonging the rise in intracellular Ca2+ signaling. Studies were made in wild-type (wt) and TRPC4 knockout (TRPC4(-/-) mice and lung vascular endothelial cells (LECs) isolated from these animals. RT-PCR showed expression of TRPC1, TRPC3,...

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Source

Identifiers

PMID: 12114324
DOI: 10.1161/01.res.0000023391.40106.a8

Genes

TRPC4
TRPC1
TRPC3
TRPC6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Impairment of store-operated Ca2+ entry in TRPC4(-/-) mice interferes with increase in lung microvascular permeability.PMID 12114324Read ↗

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