Article
TPC1 deficiency or blockade augments systemic anaphylaxis and mast cell activity.
Proceedings of the National Academy of Sciences of the United States of America - 28 Jul 2020
Arlt Elisabeth, Fraticelli Marco, Tsvilovskyy Volodymyr, Nadolni Wiebke, Breit Andreas, O'Neill Thomas J, Resenberger Stefanie, Wennemuth Gunther, Wahl-Schott Christian, Biel Martin, Grimm Christian, Freichel Marc, Gudermann Thomas, Klugbauer Norbert, Boekhoff Ingrid, Zierler Susanna
Abstract excerpt
Mast cells and basophils are main drivers of allergic reactions and anaphylaxis, for which prevalence is rapidly increasing. Activation of these cells leads to a tightly controlled release of inflammatory mediators stored in secretory granules. The release of these granules is dependent on intracellular calcium (Ca2+) signals. Ca2+ release from endolysosomal compartments is mediated via intracellular cation...
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