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Article

Abrogation of thrombin-induced increase in pulmonary microvascular permeability in PAR-1 knockout mice.

Physiological genomics - 18 Dec 2000

Vogel S M, Gao X, Mehta D, Ye R D, John T A, Andrade-Gordon P, Tiruppathi C, Malik A B

Abstract excerpt

We investigated the function of proteinase-activated receptor-1 (PAR-1) in the regulation of pulmonary microvascular permeability in response to thrombin challenge using PAR-1 knockout mice (-/-). Lungs were isolated and perfused with albumin (5 g/100 ml)-Krebs solution at constant flow (2 ml/min). Lung wet weight and pulmonary artery pressure (P(pa)) were continuously monitored. We determined the capillary...

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Source

Identifiers

PMID: 11120874
DOI: 10.1152/physiolgenomics.2000.4.2.137

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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