Article
Heteromeric TRPV4-C1 channels contribute to store-operated Ca(2+) entry in vascular endothelial cells.
Cell calcium - 1 Dec 2011
Ma Xin, Cheng Kwong-Tai, Wong Ching-On, O'Neil Roger G, Birnbaumer Lutz, Ambudkar Indu S, Yao Xiaoqiang
Abstract excerpt
There is controversy as to whether TRP channels participate in mediating store-operated current (I(SOC)) and store-operated Ca(2+) entry (SOCE). Our recent study has demonstrated that TRPC1 forms heteromeric channels with TRPV4 in vascular endothelial cells and that Ca(2+) store depletion enhances the vesicle trafficking of heteromeric TRPV4-C1 channels, causing insertion of more channels into the plasma membrane...
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