Article
TRPC3 mediates T-cell receptor-dependent calcium entry in human T-lymphocytes.
The Journal of biological chemistry - 18 Jul 2003
Philipp Stephan, Strauss Bettina, Hirnet Daniela, Wissenbach Ulrich, Mery Laurence, Flockerzi Veit, Hoth Markus
Abstract excerpt
Stimulation of the T-cell receptor (TCR) activates Ca2+ entry across the plasma membrane, which is a key triggering event for the T-cell-associated immune response. We show that TRPC3 channels are important for the TCR-dependent Ca2+ entry pathway. The TRPC3 gene was found to be damaged in human T-cell mutants defective in Ca2+ influx. Mutations of the TRPC3 gene were accompanied by changes of TRPC3 gene...
Topics
- Barium
- Calcium Signaling
- DNA, Complementary
- Gene Expression
- Genotype
- Humans
- Inositol 1,4,5-Trisphosphate
- Ion Channels
- Ion Transport
- Jurkat Cells
- Lymphocyte Activation
- Mutation
- Receptors, Antigen, T-Cell
- Recombinant Proteins
- T-Lymphocytes
- TRPC Cation Channels
- Thapsigargin
- Transfection