Article

A Single Mutation in TRPC6 Protects Mice from Acute Lung Injury by Regenerating Endothelium

2025-02-20

Abstract excerpt

Regenerating vascular endothelium under sepsis, trauma, and viral infections is vital for promoting the resolution of inflammatory diseases such as acute lung injury (ALI). Transient receptor potential canonical (TRPC) channels mediated Ca 2+ entry compromises organ functions and survival from lung injury. Through decoding the domain in TRPC6 responsible for vascular injury, we unveiled the intricate molecular me...

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Literature Corpus work: 614ca392-5e62-5e4c-a08d-4dd616d9482c
DOI: 10.1101/2025.02.19.639142

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