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Article

Deletion of Orai2 augments endogenous CRAC currents and degranulation in mast cells leading to enhanced anaphylaxis.

Cell calcium - 1 May 2018

Tsvilovskyy Volodymyr, Solís-López Alejandra, Schumacher Dagmar, Medert Rebekka, Roers Axel, Kriebs Ulrich, Freichel Marc

Abstract excerpt

All three members of the Orai family of cation channels-Orai1, Orai2 and Orai3-are integral membrane proteins that can form store-operated Ca2+ channels resembling endogenous calcium release-activated channels (CRAC) in many aspects. Loss of function studies in human and murine models revealed many functions of Orai1 proteins not only for Ca2+ homeostasis, but also for cellular and systemic functions in many cell...

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Identifiers

PMID: 29604961
DOI: 10.1016/j.ceca.2017.11.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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