Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Calreticulin reveals a critical Ca(2+) checkpoint in cardiac myofibrillogenesis.

The Journal of cell biology - 8 Jul 2002

Li Jian, Pucéat Michel, Perez-Terzic Carmen, Mery Annabelle, Nakamura Kimitoshi, Michalak Marek, Krause Karl-Heinz, Jaconi Marisa E

Abstract excerpt

Calreticulin (crt) is an ubiquitously expressed and multifunctional Ca(2+)-binding protein that regulates diverse vital cell functions, including Ca(2+) storage in the ER and protein folding. Calreticulin deficiency in mice is lethal in utero due to defects in heart development and function. Herein, we used crt(-/-) embryonic stem (ES) cells differentiated in vitro into cardiac cells to investigate the molecular...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Benzothiazoles
Share to Calreticulin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chelating Agents

Share to Diamines

Share to Ionomycin

Share to Ionophores

Share to Muscle Development

Share to Organic Chemicals

Source

Open in PubMed Open full text

Identifiers

PMID: 12105184
DOI: 10.1083/jcb.200204092
PMCID: PMC2173019

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Calreticulin reveals a critical Ca(2+) checkpoint in cardiac myofibrillogenesis.PMID 12105184Read ↗

Calreticulin signals upstream of calcineurin and MEF2C in a critical Ca2+-dependent signaling cascadeSemantic proximity Read ↗

Calreticulin is essential for cardiac development.Semantic proximity Read ↗

Cardiac-specific Expression of Calcineurin Reverses Embryonic Lethality in Calreticulin-deficient MouseSemantic proximity Read ↗

Egr-1 negatively regulates calsequestrin expression and calcium dynamics in ventricular cells.Semantic proximity Read ↗

Cardiac myosin-binding protein C is required for complete relaxation in intact myocytes.Semantic proximity Read ↗

Pharmacological or genetic inhibition of LTCC promotes cardiomyocyte proliferation through inhibition of calcineurin activity.Semantic proximity Read ↗

Myocardin is sufficient and necessary for cardiac gene expression in Xenopus.Semantic proximity Read ↗

REEP5 depletion causes sarco-endoplasmic reticulum vacuolization and cardiac functional defectsSemantic proximity Read ↗

Calreticulin, a Calcium-binding Molecular Chaperone, Is Required for Stress Response and Fertility in<i>Caenorhabditis elegans</i>Semantic proximity Read ↗

Calcium extrusion is critical for cardiac morphogenesis and rhythm in embryonic zebrafish hearts.Semantic proximity Read ↗

Modulation of sarcoplasmic reticulum calcium release by calsequestrin in cardiac myocytes.Semantic proximity Read ↗

Cyclin D2 rescues size and function of GATA4 haplo-insufficient hearts.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.