Article
Myocardin is sufficient and necessary for cardiac gene expression in Xenopus.
Development (Cambridge, England) - 1 Mar 2005
Small Eric M, Warkman Andrew S, Wang Da-Zhi, Sutherland Lillian B, Olson Eric N, Krieg Paul A
Abstract excerpt
Myocardin is a cardiac- and smooth muscle-specific cofactor for the ubiquitous transcription factor serum response factor (SRF). Using gain-of-function approaches in the Xenopus embryo, we show that myocardin is sufficient to activate transcription of a wide range of cardiac and smooth muscle differentiation markers in non-muscle cell types. We also demonstrate that, for the myosin light chain 2 gene (MLC2),...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.