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Article

Cardiac-specific Expression of Calcineurin Reverses Embryonic Lethality in Calreticulin-deficient Mouse

1 Dec 2002

Abstract excerpt

Calreticulin is an endoplasmic reticulum resident Ca(2+)-binding chaperone. The importance of the protein is illustrated by embryonic lethality because of impaired cardiac development in calreticulin-deficient mice. The molecular details underlying this phenotype are not understood. In this study, we show that overexpression of activated calcineurin reverses the defect in cardiac development observed in...

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PMID: 12377773
DOI: 10.1074/jbc.m209900200

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Source receipt: pubmed, retrieved 7 Sept 2026.

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