Calreticulin, a Calcium-binding Molecular Chaperone, Is Required for Stress Response and Fertility in<i>Caenorhabditis elegans</i>

Abstract excerpt

Calreticulin (CRT), a Ca(2+)-binding protein known to have many cellular functions, including regulation of Ca(2+) homoeostasis and chaperone activity, is essential for heart and brain development during embryogenesis in mice. Here, we report the functional characterization of Caenorhabditis elegans calreticulin (crt-1). A crt-1 null mutant does not result in embryonic lethality but shows temperature-dependent...

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