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Article

Calcium extrusion is critical for cardiac morphogenesis and rhythm in embryonic zebrafish hearts.

Proceedings of the National Academy of Sciences of the United States of America - 6 Dec 2005

Ebert A M, Hume G L, Warren K S, Cook N P, Burns C G, Mohideen M A, Siegal G, Yelon D, Fishman M C, Garrity D M

Abstract excerpt

Calcium entry into myocytes drives contraction of the embryonic heart. To prepare for the next contraction, myocytes must extrude calcium from intracellular space via the Na+/Ca2+ exchanger (NCX1) or sequester it into the sarcoplasmic reticulum, via the sarcoplasmic reticulum Ca2+-ATPase2 (SERCA2). In mammals, defective calcium extrusion correlates with increased intracellular calcium levels and may be relevant...

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Identifiers

PMID: 16314582
DOI: 10.1073/pnas.0502683102
PMCID: PMC1308882

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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