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Article

REEP5 depletion causes sarco-endoplasmic reticulum vacuolization and cardiac functional defects

19 Feb 2020

Abstract excerpt

Abstract The sarco-endoplasmic reticulum (SR/ER) plays an important role in the development and progression of many heart diseases. However, many aspects of its structural organization remain largely unknown, particularly in cells with a highly differentiated SR/ER network. Here, we report a cardiac enriched, SR/ER membrane protein, REEP5 that is centrally involved in regulating SR/ER organization and cellular...

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PMID: 32075961
DOI: 10.1038/s41467-019-14143-9

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